Maurizio Sarri has left Eden Hazard out of Chelsea’s travelling 21-man squad for their Europa League group-stage opener at PAOK Salonika.
The Belgian forward, 27, scored a hat-trick against Cardiff at the weekend but has not made the trip to Greece.
However, the likes of Gary Cahill, Cesc Fabregas and Ethan Ampadu should all come into consideration.
Wales midfielder Ampadu, 18, signed a new five-year contract with the Blues on Wednesday.
Fabregas, 31, has not started a game for Chelsea since their Community Shield defeat by Manchester City.
But the Spanish midfielder returned to training last week after struggling with a knee injury.
England midfielder Ruben Loftus-Cheek may also feature if he has recovered fully from a problem with his right tibia that kept him out against the Bluebirds.
Chelsea squad: Kepa Arrizabalaga, Willy Caballero, Marcin Bulka, Toni Rudiger, Marcos Alonso, Cesc Fabregas, Jorginho, N’Golo Kante, Ross Barkley, Pedro, Ruben Loftus-Cheek, Victor Moses, Olivier Giroud, Callum Hudson-Odoi, Davide Zappacosta, Willian, Gary Cahill, Andreas Christensen, Cesar Azpilicueta, Alvaro Morata, Ethan Ampadu.